Weight Loss / Generic Acomplia
Acomplia (Rimonabant) is a new miraculous multifunctional diet pill. According to a report published by the Journal of the American Medical Association, Accomplia produces sustained weight loss helps to quit smoking improves blood makers improves high-density lipoprotein (HDL) cholesterol and triglyceride levels
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Most popular quantity. What is Acomplia? Acomplia (Rimonabant) is the first in a new class of therapeutic agents called Cannabinoid-1 Receptor Blockers (CB1). Acomplia is used in the treatment of obesity and related conditions. How does Acomplia work? Acomplia acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle1. Acomplia switches off the same brain circuits that make people hungry when they smoke cannabis. CB1 receptor blockade with Acomplia acts to decrease the overactivity of the endocannabinoid system (EC system)2,3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism. What is Acomplia used for? Acomplia is used complementary to diet and exercise to treat obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the blood. Sanofi argues that Acomplia can also prevent the risk of cardiovascular disease. Patients with large waist circumference (102 cm in men and 88 cm in women) will mostly benefit from taking the drug. Does Acomplia also aid smoking cessation? Acomplia has been studied by sanofi-aventis as an aid to smoking cessation based on studies for up to one year in over 6,500 smokers motivated to quit smoking. Sanofi-aventis submitted a New Drug Application to the FDA, which in turn issued a non approvable letter for Acomplia for use in smoking cessation. An approvable letter was however issued for Acomplia for use in weight management. Acomplia has just been approved in the European Union. Is Acomplia approved in the United States? No. Sanofi is still awaiting U.S. marketing go-ahead which it has said could come by the end of this year. U.S. health authorities have asked Sanofi for more information on Acomplia. Acomplia received European Union marketing approval in June 2006. The first launch will take place in Britain in July and be followed by launches in Denmark, Ireland, Germany, Finland and Norway in the second half of this year, according to Sanofi. What were the results of Acomplia Clinical trial studies? In clinical studies, Acomplia has been shown to improve a wide array of cardiometabolic risk factors as well as promoting sustained weight loss4,5. Approximately half of the observed improvement in HDL-cholesterol, triglycerides and HbA1C (an indicator of blood sugar control) in patients who received Acomplia 20mg was beyond that expected from weight loss alone. What are the side-effects of Acomplia? Side effects in the trial on Acomplia in obesity were vomiting and nausea, forcing about 19 percent of patients to leave the trial versus 13 percent of those who took placebo. The drug information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects.  This information is generalized and is not intended as specific medical advice.  If you have questions about the medicines you are taking or would like more information, check with your doctor, pharmacist or other healthcare professional.

A HUNGRY AND HURTING: EMOTIONAL AND PHYSICAL ABUSE (MARTHA’S STORY)

MARTHA: "I didn't have a clue about how to connect with people."

Martha, a thirty-seven-year-old Jewish lesbian mother, links the onset of her compulsive eating to emotional abuse she suffered as a child, abuse that made her feel "disconnected from the world." She never learned the basic lesson of "connecting with other people" that she believes comes from allowing children to be themselves and trust others and nurturing them emotionally and physically. Martha describes herself in terms characteristic of abused children, portraying herself as a lost soul who lacked direction, roots, and a sense of belonging to anyone, including herself.4 She was almost always alone when she was a child. She has almost no memories of the time before she was eleven.

Martha grew up in a home in which she was deprived of basic physical and emotional care. There was no touching; she sometimes pretended to be asleep so her father would pick her up and carry her to bed, providing at least a moment of physical contact. Her father was rarely home because he worked nights. One of Martha's sisters treated her as if she were the family's maid. Another was emotionally cruel to her, keeping Martha from her friends and simultaneously telling Martha that any friends she had were a result of her sister's popularity.

Nor did Martha know how to reach out for attention or friends at school. When she made her first friend, in eighth grade, and told her mother about it, her mother said, "Don't get too excited because as high as you will be is as far as you will fall. These people will hurt you." It was a slap in the face, a punch in the chest. Martha cried as she told me the story: "I opened my heart a little and she pulled it down. A lot of emotional abuse and neglect.

The family labeled Martha overly sensitive and teased her incessantly. She cannot remember ever eating a meal with her family when she did not break down and cry because of the teasing. She watched between ten and twelve hours of television each day, even on school days. She knows she was a bright child because she was able to do well in school even though she never studied. There were no books in the house, and she didn't know how to seek them out. She was mildly dyslexic but no one realized it when she was growing up. She was repeatedly told by the members of her family that she was fat and ugly and had no personality. She had no sense of her body size or whether or not she was attractive.

Her mother controlled what Martha and her sisters ate. Even though her sisters were fat and her mother was obese and a compulsive eater, Martha was the one considered to have the biggest problem with food. She was always served last and castigated for eating. Her mother took her to a diet doctor when Martha was eleven and continued to limit her food. Yet her mother also participated in Martha's bingeing. Martha remembers being told by her mother that she could have three cookies each day when she got home from school. Martha would eat three cookies, want more, think about it, and then have more. Then she would struggle to decide whether' to get more and usually did, typically stopping after finishing a dozen cookies. Her mother would come home and ask her how many she ate. Martha would lie and say three. Her mother never questioned this openly, although she was the one who filled the cookie jar every day. Although Martha was obviously compulsively eating and lying, no one said anything.

Eating compulsively was how Martha comforted herself from the pain of not feeling connected to any person or to the rest of the world. Bingeing calmed her, leaving her feeling drugged and dazed. When I asked her if she thinks she ate compulsively out of fear of her feelings, she said it wasn't as if she had feelings and then ate to get rid of them. That would assume she had feelings to begin with. That would assume some connection. She ate from disconnection. No specific feelings triggered eating. Simply being triggered her desire to eat. She ate, felt numb, and watched television. And no one seemed to care.